클리닉 소개

Obsessive-Compulsive Disorder Clinic

연구 및 치료성과

Identification of altered protein expression in major depressive disorder and bipolar disorder patients using liquid chromatography–tandem mass spectrometry
Journal
Psychiatry Research
Vol
299
Author
Hyeyoung Kim, Sang Jin Rhee, Hyunju Lee, Dohyun Han, Tae Young Lee, Minah Kim, Eun Young Kim, Jun Soo Kwon, Hyunsuk Shin, Hyeyoon Kim, Yong Min Ahn, Kyooseob Ha
Year
2021

Abstract

Emerging high-throughput proteomic technologies have recently been considered as a powerful means of identifying substrates involved in mood disorders. We performed proteomic profiling using liquid chromatography–tandem mass spectrometry to identify dysregulated proteins in plasma samples of 42 and 45 patients with major depressive disorder (MDD) and bipolar disorder (BD), respectively, in comparison to 51 healthy controls (HCs). Fourteen and six proteins in MDD and BD patients, respectively, were differentially expressed compared to HCs, among which coagulation factor XIII A chain (F13A1), platelet basic protein (PPBP), platelet facor 4 (PF4), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and thymosin beta-4 (TMSB4X) were altered in both disorders. For proteins dysregulated in both, except F13A1, higher fold changes were observed in MDD than in BD patients. These findings may help identify candidate biomarkers of mood disorders and elucidate their underlying pathophysiology and biochemical abnormalities.